Project 12 · Bioinformatics
BIO
ProteinExplorer
Protein Structure Analysis Tool
01 Abstract
Protein Structure Analysis Tool
An interactive protein sequence analysis toolkit covering hydrophobicity, secondary-structure prediction, pairwise alignment, and physicochemical property estimation with SVG dashboards.
02 Highlights
Methods & contributions
- Sequence biochemistry — monoisotopic and average residue masses, Kyte–Doolittle hydropathy, side-chain pKa/pI via Henderson–Hasselbalch.
- Alignment — Needleman–Wunsch with affine (Gotoh) gaps scored on the full BLOSUM62 matrix.
- Structure prediction — Chou–Fasman secondary-structure propensities and disorder prediction.
- Visualization — SVG-based profiles served through a FastAPI dashboard.
03 Architecture
Data flow
sequence → hydropathy + composition
→ Chou–Fasman SS · disorder
→ Needleman–Wunsch (BLOSUM62) alignment → SVG
04 Stack